Manipal Entrance Test For MPharm and PharmD - Syllabus Of Pharmacognosy And Pharmaceutics

✓ PHARMACOGNOSY

1. Cultivation, collection and post-harvest technology of crude drugs: Introduction, cultivation, collection, drying storage and preservation of crude drugs of natural origin, factors influencing cultivation, plant hormones and their applications.

2. Adulteration and evaluation of crude drugs: Methods of adulteration and evaluation - Organoleptic, Microscopical, Physical, Chemical and Biological methods.

3. Plant secondary metabolites: Introduction, definition, distribution, properties, classification, extraction, chemistry and tests for identification of Carbohydrates, Tannins, Lipids, Proteins, Essential oils, Resins, Alkaloids and Glycosides. Systematic Pharmacognostic studies of following drugs: Carbohydrates: Acacia, Tragacanth, Sterculia, Guar gum, Agar, Starch, Cellulose, Honey Alginate, carrageenan, Isapgol; Tannins: Catechu (pale & black), Nutgall, Asoka, Arjuna, Kino; Lipids: Castor oil, Cocoa Butter, Olive oil, Shark liver oil, Wool fat, Beeswax, Spermaceti, Chaulmoogra oil, Linseed oil, Arachis oil, Sesame oil, Kokum butter; Proteins: Gelatin and its products, Collagen; Essential oils: Fennel, Mentha, Cinnamon, Lemon grass, Clove, Nutmeg, Cardamom, Eucalyptus, Coriander, Caraway, Dill, Ajowan, Valerian, Jatamansi, Rasna, Garlic, Acorous, Lemon and Orange peel, Musk, Gaultheria, Sandal wood, Tulsi, Lavender, Artemisia, Coleus, Crocus; Resins: Cannabis, Podophyllum, Ginger, Capsicum, Colophony, Asafoetida, Benzoin Myrrh, Guggul, Turmeric, Boswellia; Alkaloids: Datura, Belladonna, Hyoscyamus, Coca, Rauwolfia, Nux vomica, Ergot, Catharanthus, Aswagandha, Cinchona, Ipecac, Opium, Vasaka, Pepper, Lobelia, Tobacco, Kurchi, Tea, Aconite, Ephedra, Colchicum; Glycosides: Digitalis, Squill, Strophanthus, Aloe, Senna, Rhubarb, Cascara, Licorice, Ginseng, Dioscorea, Gokhru, Senega, Wild cherry bark, Bitter almond, Mustard, Linseed, Citrus peel, Milk thistle, Psoralea, Gingko, Ammi, Gentian, Chirata, Quassia, Kalmegh, Hypericum, Artichoke.

4. Introduction to phytochemistry: Preliminary phytochemical screening of natural products. General methods used for the extraction, isolation and purification of phytoconstituents. A brief account of spectroscopic and chromatographic methods used for evaluation of Phytoconstituents.

5. Plant biosynthesis: Introduction, Techniques employed for the elucidation of biosynthetic pathways. Study of basic metabolic pathways - Shikimic acid, Isoprenoid and Acetate pathway. Biosynthesis of Tropane (Hyoscyamine/Hyoscine), Quinoline (Cinchona alkaloids), Isoquinoline (Papaverine), Phenanthrene (Morphine) and Indole alkaloids (Lysergic acid derivatives), Biosynthesis of Steroidal glycosides (C-23 and C-24) digitoxin.

6. Natural pesticides of plant origin: Introduction, classification of pests, methods of pest control, classification of pesticides based on mode of action. Natural drugs used as Pesticides-Pyrethrum, Neem, Tobacco, Red Squill.

7. Enzyme biotechnology: Introduction, classification, general methods of isolation and purification of enzymes, enzyme reactors and applications of immobilized enzymes in drug analysis. Source, methods of preparation, chemical nature and uses of the Papain, Bromelain, Streptokinase, Urokinase, Asparginase, Diastase, Pepsin, Trypsin, Pancreatin.

8. Plant tissue culture: Introduction, types of culture, methods and their application. Callus and suspension culture, protoplast isolation and fusion, Biotransformation and immobilization, Production of secondary metabolites, transgenic plants and their applications.

9. Herbal formulations and standardization: Introduction and classification, General considerations, Selection of dosage form, Stages of herbal formulation, Herbal dosage forms, Formulation and standardization, WHO guidelines for the assessment of herbal medicine, Marker based standardization of herbal drugs by HPLC and HPTLC.

10. Nutraceuticals and cosmeceuticals: Introduction, classification with examples and importance. Natural products used as nutraceuticals: Antioxidants, PUFA, probiotics, prebiotics, dietary fibers. Natural products used as cosmeceuticals: Skin care, hair care products, source, active constituents and uses of Soy bean, Spirulina, Garlic, Aloes, Tea, Turmeric.

✓ PHARMACEUTICS
Physical Pharmacy: Buffers, Solubility, Viscosity and rheology, Surface and interfacial phenomenon, Dispersion systems, Complexation, Micromeritics and Powder rheology.

Dispensing Pharmacy: Introduction to laboratory equipment, weighing methodology, handling of prescriptions, labelling instructions for dispensed products, Posological calculations, Available dosage forms and packing, Compounding and dispensing of prescriptions, Enlarging and reducing formula, Displacement value, Preparations of formulations involving allegation, alcohol dilution and isotonic solution.

Pharmaceutical Technology: Pharmacy Profession & Introduction to Pharmaceuticals, Introduction to dosage forms, Pharmaceutical Plant, Location and layout, Ophthalmic preparations, Preformulations, Packaging materials, Cosmetics, Pilot plant scale-up techniques, Dosage form necessities and additives, Powders, Sources of drug information, Tablets, Parenterals, Suspensions, Emulsions, Suppositories, Stability of formulated products, Prolonged action pharmaceuticals, Novel drug delivery systems, Semisolids, Allergenic extract, Capsules, Liquids (syrups, elixirs, spirits, aromatic water, liquid for external uses), Pharmaceutical aerosols.

Pharmaceutical Engineering: Material of constructions, Drying, Size reduction and Size separation, Extraction, Mixing, Crystallization, Industrial hazards & safety precautions, Evaporation, Distillation, Filtration and Centrifugation.

Biopharmaceutics and Pharmacokinetics: Biopharmaceutics, Bio-pharmaceutical statistics and Bio-availability & Bio-equivalence.

2022